Searchable abstracts of presentations at key conferences in endocrinology

ea0029p1200 | Obesity | ICEECE2012

Acute ghrelin effects on depressive-like behavior in bulbectomyced mice: a possible mechanism of action

Carlini V. , Martini A. , Kumar P. , Sawant R. , Rask-Andersen M. , Fredriksson R. , Rubiales de Barioglio S. , Schioth H. , Fiol de Cuneo M.

Ghrelin (Ghr) is an orexigenic peptide investigated by Lutter and col. 2008 for its potential role in the development of depressive symptoms induced by chronic stress, suggesting that Ghr defends against depressive-like symptoms. Rodent bilateral olfactory bulbectomy (OB) is an animal model that appears to fulfill many of the criteria required for the study of depression; hence, Ghr could be an alternative therapeutic tool for depression therapy. We study the possibility that ...